Treatment-related myelodysplastic syndrome: molecular characteristics and therapy

Therapy-related myelodysplastic syndrome: a case study.

We present a case of therapy-related myelodyspastic syndrome in which the t(3;8)(q26;q24) translocation appeared, even though no chromosomal abnormalities were found at the initial diagnosis of acute myeloid leukemia. To the best of our knowledge, there have only been around 20 reported cases of myeloid malignancies involving t(3;8)(q26;q24). We discuss the characteristics of t(3;8)(q26;q24) al...

Azacitidine in the treatment of pediatric therapy-related myelodysplastic syndrome after allogeneic hematopoietic stem cell transplantation.

We herein present a case of pediatric therapy-related myelodysplastic syndrome (t-MDS) with complex karyotype who was treated with azacitidine (AZA) for AML1-EVI1 fusion transcript as minimal residual disease after allogeneic hematopoietic stem cell transplantation (HSCT). The patient was started on AZA 41 days after the HSCT without having achieved complete remission. After 9 cycles of AZA, th...

Differentiation therapy for myelodysplastic syndrome.

Nearly 20 years ago in 1982, one of us wrote a review for Blood about the therapeutic potential of differentiation therapy (1). This was shortly after the initial studies with HL-60 myeloblastic leukemia cells showing that a variety of agents, including retinoids, could induce their terminal differentiation. This was followed by the finding that retinoids, especially ATRA, could cause terminal ...

Risk stratification in therapy-related myelodysplastic syndromes

Therapy-related acute myeloid leukemia and myelodysplastic syndrome: a clinical and morphologic study of 65 cases.

This study consists of 65 patients (pts) who developed a myelodysplastic syndrome (MDS) (39 pts) or acute myeloid leukemia (AML) (26 pts) following chemotherapy and/or radiotherapy; the interval from the onset of therapy to bone marrow abnormality ranged from 11 to 192 months (median, 58). Thirty-three patients had been previously treated for lymphoproliferative diseases, 29 for carcinoma, and ...